Showing posts with label disease. Show all posts
Showing posts with label disease. Show all posts
Wednesday, May 17, 2017
PTAB Institutes IPR of Alethia Biotherapeutics Patent Claiming Use of mAb to Treat Bone Disease
PTAB Institutes IPR of Alethia Biotherapeutics Patent Claiming Use of mAb to Treat Bone Disease
On June 15, 2015, the Patent Trial and Appeal Board (PTAB) instituted inter partes review (IPR) with respect to claims 1-6, 8-11, and 15-23 of US Patent Number 8,168,181 (Case IPR2015-00291). The ’181 patent discloses "methods of modulating osteoclast differentiation, which may be useful in the treatment of bone loss or bone resorption in patients suffering or susceptible of suffering from a certain conditions such as osteoporosis."
Claim 1 is representative.
1. A method of impairing osteoclast differentiation in a mammal in need thereof, the method comprising administering an antibody or antigen binding fragment which specifically binds to human Siglec-15 (SEQ ID NO.:2) or murine Siglec-15 (SEQ ID NO.:108) to said mammal.
The patent owner is Alethia Biotherapeutics, a Montreal-based biotechnology company “[e]ngaged in the discovery and development of therapeutic mAbs against highly-disease tissue specific novel clinically-relevant targets.” The petitioner is Daichi Sankyo, a Japanese pharmaceutical company. According to Alethia Biotherapeutics, the two companies are developing competing products for treating bone disease based on anti-Siglec-15 antibodies that inhibit osteoclast differentiation.
The PTAB determined that there is a reasonable likelihood that Petitioner would prevail in demonstrating the unpatentability of the challenged claims as anticipated by a published PCT application, Yoshiharu Hiruma et al., WO 2009/048072. The Hiruma reference is Daichi Sankyos own PCT application, and the two companies appear to be attempting to patent similar same subject matter.
A critical issue in the case is whether the challenged claims are able to benefit from the filing date of a parent application. The filing date of the ‘181 patent is October 16, 2009, but it claims priority to a continuation-in-part filed January 13, 2009, and a PCT application filed February 13, 2007. The prior art, Hiruma, published on April 16, 2009. Thus, If Alethia is able to claim priority to the earlier filed applications, then Hiruma is not prior art. But Daichi Sankyo argues that the earlier filed applications do not satisfy the written description and enablement requirements of Section 112 with respect to the challenged claims, and thus that the claims are entitled to a priority date “no earlier than April 16, 2009.”
In granting the petition, the PTAB found that “Petitioner has presented sufficient evidence, on the present record, to persuade us that the challenged claims of the ’181 patent are entitled to a priority date no earlier than April 16, 2009, on the basis of lack of adequate written description support and/or enablement of the claim subject matter in the Parent Application.
In its Preliminary Response, the Patent Owner argued that the petition should be denied because in related proceedings the PTO and PTAB have already addressed, or are currently addressing, petitioner’s arguments concerning the alleged lack of 112 support for the parent applications. The Patent Owner also argued that Petitioner should be precluded from making arguments based on 112, i.e., lack of enablement and written description, because by statute IPR is limited to challenges based on 102 and 103, i.e., lack of novelty and obviousness. The PTAB rejected these arguments, at least for the purpose of deciding the question of whether the review should be instituted.
The PTAB decision points out that “Patent Owner does not dispute at this time that Hiruma discloses the limitations recited in the challenged claims.” For strategic reasons, it is not uncommon for patent owners to hold back some of their best arguments at the Preliminary Response stage, saving them to use in their full Response, which is only necessary in the event IPR is instituted. This could be what is going on here.
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Monday, March 27, 2017
Powerful Herbs and Spices that Slow Aging Boost Metabolism and Fight Disease
Powerful Herbs and Spices that Slow Aging Boost Metabolism and Fight Disease
Spices can collectively help your skin look younger and softer. Many spices contain antioxidants which protect your skin from sun dent and help you overcome aging. Since they are rich in antioxidants they act as anti-aging agents .They firm up your skin by keeping it moisturised. They also remove some toxins. In fact, many herbs and spices rank even higher in antioxidant activity than fruits and vegetables, some spices such as cloves, turmeric, and cinnamon are having as much as 10 to 50 times more antioxidants compared to the blueberry.
The benefits of the antioxidants in these spices include protection against most serious degenerative diseases like cancer, heart disease, diabetes, arthritis, macular degeneration, Alzheimer’s, and overall aging.
Herbs and Spices Health Benefits
- Fat Burning and Boost Metabolism – Mostly herbs and spices are thermogenic, which means they naturally help to increase metabolism, partly because they have more nutrient.
- Stabilize Blood Sugar – Some spices are also good at regulating blood sugar and controlling insulin–even as good as some diabetic drugs! When your blood sugar is well controlled, you are more likely to burn fat and not store calories as excess weight.
- Anti-Inflammatory Properties –Studies show that herbs and spices can actually work as well or better than some medications at calming inflammation without the negative side effects of isolated drugs.
- Anti-bacterial, anti-viral, anti-fungal – Herbs and spices contain properties that effectively kill dangerous pathogens like viruses, bacteria and stubborn fungi. The natural properties in these foods work against many microbes that are resistant to conventional medications.
7 Most Powerful anti-aging herbs and spices
TurmericTurmeric has yellow-orange pigment, curcumin, is the main active ingredient in the spice. Amazingly, curcumin’s anti-inflammatory benefits are comparable to drugs like hydrocortisone and over-the-counter anti-inflammatory medicines like Advil and Motrin. But, unlike the drugs, curcumin is not toxic at all, it does not have the dangerous side effects.
Curcumin is more effective at slowing down the development of Alzheimer’s disease than many medications, because it decreases inflammation and oxidation in the brain. This spice also speeds up the recovery time from strokes as well.
Turmeric and its active ingredient, curcumin, are highly effective against diseases like irritable bowel disease, ulcerative colitis, Crohn’s, and arthritis. Turmeric also improves liver function, lowers homocysteine and prevents heart disease. Turmeric has anti-inflammatory property, it can help reduce joint pain and aid in healing joint problems over time.
Paprika
Paprika is one of the best spices to slow down ageing. It is rich in anti-oxidants like vitamin A and C. It absorbs the free radicals which cause damage to the collagen of the skin and helps in maintaining firmness. Applying of paprika on the skin makes you feel relaxed and fresh.
Spices are used in detox drinks and in regular diet. Thus consuming them orally or applying them on skin gives you a natural benefit.
Cinnamon
The superfood provided those cultures with an abundance of nutrients, and was also used for medicinal purposes, treating inflammation, infections, poisonous bites, and respiratory infections. It makes sense—two teaspoons of ground cinnamon provides you with 45.5% of your daily requirement of manganese, 11% of fiber DV, and 5.2% of your calcium. The superfood is also a beneficial source of iron, containing 8.3 mg per 100 g.
Cinnamon also has anti-inflammatory properties, such as relieves pain and stiffness in muscles and joints, including arthritis, reduces inflammation in blood vessels that leads to atherosclerosis and heart disease, as well as anti-fungal and antibacterial.
Cumin
Cumin is another spice that is especially high in antioxidants, but cumin is known for being especially good for digestion. It stimulates the gallbladder and pancreas to secrete enzymes and bile that break down food into usable nutrients your body can use.
Due to the high antioxidant content, Cumin can help fight inflammation throughout the body, and thereby helps in slowing down the aging process.
Cumin also helps detoxify the body, and is highly effective for respiratory disorders like asthma and bronchitis.
Ginger
ginger as an effective, low-cost treatment for motion sickness and nausea, and I’m sure many of you have used it for this purpose. I’ve also reported at length on its effectiveness in preventing migraine headaches, healing burns, and alleviating the pain and inflammation of rheumatoid arthritis.
A great everyday tea is a freshly made ginger tea. Simply steep several slice of ginger root in warm water with the juice of half a lemon to help with bloating, digestion, and inflammation. This tea is also an everyday detox and you will notice after several weeks an improvement in the clarity of your skin. It may also be effective in weight loss.
Ginger is also a wonderful food to cook with, giving your dishes a spicy flavor lessening the needs to use salt.
Fenugreek
Fenugreek is a cooling and soothing agent. You can soak them over night and can drink the water in the morning which may help you exhaust your body heat. Applying this water on the skin and over the eyes gives you a great cooling effect and a brighter, shiny look. It can be used as an eye drop which will cleanse your eyes.
Oregano
Oregano is herb that contains oil that has anti-bacterial , anti-fungal and anti-viral agent, rosmarinic acid (also found in rosemary) properties. Oregano oil has been used to treat a wide range of conditions from bacterial and viral infections, to parasites and stubborn fungal infections. Although oil of oregano is most often used for medicinal purposes, the herb itself can provide many of the same benefits when consumed regularly.
Oregano also relieves inflammation, internal or external, and can offer relief from allergies, aches and pain, without side effects. Oregano is very high in antioxidants, it helps fight radicals and quelling inflammation.
source.www.naturalnews.com
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